Scientific papers 2023
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Authors:
Feiko J. M. de Jong, Thijs T. Wingelaar, Paul Brinkman,
Pieter-Jan A. M. van Ooij, Anke H. Maitland-van der Zee,
Markus W. Hollmann, and Rob A. van Hulst
The COMEX-30 hyperbaric treatment table is used to
manage decompression sickness in divers but may result in
pulmonary oxygen toxicity (POT). Volatile organic
compounds (VOCs) in exhaled breath are early markers of
hyperoxic stress that may be linked to POT. The present
study assessed whether VOCs following COMEX-30
treatment are early markers of hyperoxic stress and/or POT
in ten healthy, nonsmoking volunteers.
Authors:
Simona Mrakic-Sposta, Maristella Gussoni, Mauro Marzorati,
Simone Porcelli, Gerardo Bosco, Costantino Balestra,
Michela Montorsi, Claudio Lafortuna, and Alessandra
Vezzoli.
Exposure to acute hypoxia elicits several functional
changes in the human body to cope with the decreased
oxygen availability. Whereas some of these adjustments
(increased pulmonary ventilation and heart rate) are well
characterized, others are still poorly understood. Excesses
in the accumulation of reactive oxygen species (ROS),
generated within the mitochondria, drive mechanisms
contributing to injury including the induction of oxidative
damage.
Authors: Junjie Wei, Peng Xiao, and Tao Chen
Conductive gels have been developing as superior
wearable sensing materials due to their intrinsic
conductivity, softness, stretchability, and biocompatibility,
showing great potential in many aspects of our lives.
However, it is challenging for traditional conductive gels to
realize sensing applications underwater. The swelling of
gels and the loss of conductive components in the
aqueous environment, resulting from the diffusion across
the interface, lead to structural instability and sensing
performance decline. Fortunately, significant efforts have
been devoted to improving the water resistance of
conductive gels and employing them in underwater
wearable sensing in recent years, and some are exciting.
Authors: Olivier Castagna, Jean-Eric Blatteau, Arnaud
Druelle, Jordan Amara, and Jean-René Lacour
The authors suspected that oxygen uptake (VO2) and
pulmonary ventilation (VE) might be much higher than
expected during military fin swimming. In this framework,
they compared these variables in the responses of trained
military divers during land cycling and snorkeling exercises:
Eighteen male military divers participated in this study.
They performed two test exercises on two days: A maximal
incremental cycle test (land condition), and an incremental
fin swimming (fin condition) in a motorized swimming
flume.
Author: Ran Arieli
The author and his team suggest that in a “distal arterial
bubble formation”, in the bifurcating arterial tree, the
vessel’s wall becomes thinner and wall surface to the
volume of the vessel increases, both of these
circumstances enhance inert gas diffusion from the
surrounding tissue into the blood.
Authors:
Yu-Yao Zhang, Yi-Jun Zhou, Yuan-Yuan Jia, Tian-Tian
Wang, Dian-Huai Meng
Hyperbaric oxygen therapy is one of the common clinical
treatments, but adverse effects have hampered and
limited the clinical application and promotion of
hyperbaric oxygen therapy. The authors conducted a
systematic review and meta-analysis of the adverse effects
of hyperbaric oxygen therapy to provide a theoretical basis
for clinical treatment.
Authors:
Chunqin Liu, Mingyi Qin, Xiaojuan Hou, Yu Li, Zongze He
This paper reports on the treatment experience in a case
of microscope-assisted auricular replantation, targeted
postoperative treatment, early intervention with
hyperbaric oxygen therapy, and individualized nursing
care.
Authors:
Mariana Ríos-Gómez, Viviana Gómez-Ortega, Cesar
Cardona, and Jose A. De la Hoz-Valle
This systematic review aims to identify and evaluate the
clinical outcomes of hyperbaric oxygen therapy in the field
of plastic, reconstructive, and aesthetic surgery, found in
the literature from the year 2000 to the present
Authors:
Armaan K. Malhotra, Ashton P. Chang, Joseph P. Lawton,
Aderaldo Costa Alves Jr., Angela Jerath, Bourke W.
Tillmann, Harry Foster, Azad Mashari, Leodante da Costa,
and Ashish Kumar
This report describes the use of hyperbaric oxygen therapy
for the acute management of an intraoperative air
embolism encountered
during a neurosurgical procedure. Furthermore, the
authors highlight the concomitant diagnosis of tension
pneumocephalus requiring evacuation prior to hyperbaric
therapy.
Authors:
Emmanuel Gouin, Jean Eric Blatteau, Emmanuel
Dugrenot, François Guerrero, Bernard Gardette; on behalf
of Under the Pole Consortium
Scientific underwater exploration could benefit from
professional diving facilities. This could allow marine
research for durations far exceeding anything currently
possible. The closed-circuit rebreather
expansion provides new perspectives by unleashing divers
and their diving bell. “Under the Pole Expeditions”
developed an innovative compact underwater habitat for
this purpose.
Authors:
Phillip G. Durham, Awaneesh Upadhyay, Angel Navarro-
Becerra, Richard E. Moon, Mark A. Borden, Paul A. Dayton,
Virginie Papadopoulou
The method described aims to treat tumor hypoxia
microbubbles comprising oxygen as a majority component
of the gas core with a stabilizing shell that may be used to
deliver and release oxygen locally at the tumor site
through ultrasound destruction. Previous work has
revealed differences in circulation half-life in vivo for
perfluorocarbon-filled microbubbles, typically used as
ultrasound imaging contrast agents, as a function of
anesthetic carrier gas.
Authors:
David Q. LeID, Andrew H. Hoang, Arian Azarang, Rachel
M. Lance, Michael Natoli, Alan Gatrell, Lesley Blogg, Paul
A. Dayton, Frauke Tillmans, Peter Lindholm, Richard E.
Moon, Virginie PapadopoulouI
The authors report a method to generate synthetic post-
dive data using doppler ultrasound signals collected in
both precordium and subclavian vein with varying
degrees of bubbling matching field-standard grading
metrics. This method is adaptable, modifiable, and
reproducible, allowing for researchers to tune the
produced dataset for their desired purpose.
Authors: Ali Boolani, Joel Martin, Fulvio D’Acquisto, and
Costantino Balestra.
Fatigue is a complex and often misunderstood mood.
Most biomedical researchers interested in fatigue
conceptually defining fatigue as the absence of energy.
However, Loy et al. (2018) provided evidence that
biologically energy and fatigue may indeed be two
distinct unipolar moods. Since then, multiple studies have
provided evidence that energy and fatigue may have
both distinct and overlapping biological, behavioral, and
bio-mechanical correlates.
Authors:
Romain Guenneugues, Anne Henckes, Vincent
Mansourati, and Jacques Mansourati
Hyperbaric oxygen therapy (HBOT) is the standard
adjuvant treatment for life-threatening or disabling
pathologies.
Currently, mechanical and electronic variations of
implantable cardioverter-defibrillators (ICD) in hyperbaric
conditions have not been evaluated. As a result, many
patients eligible for HBOT but ICD recipients cannot
undergo this therapy, even in emergency situations.
Authors: Mehdi Abakka, MJ Mekkaoui, M. Bouffetal, RA
Bassir, M. Kharmaze, MO Lamrani, MS Berrada
Hyperbaric oxygen therapy (HBOT) is defined as a method
of administering inhaled oxygen (O2) for therapeutic
purposes under a pressure greater than atmospheric
pressure. The therapeutic benefits of HBO result, on the
one hand, from the physical effects linked to the increase
in barometric pressure and the partial pressure of O2 in
the tissues and, on the other hand, from the biological
effects linked to the production reactive species of O2 and
nitrogen. These are likely to interact with many molecular
processes responsible for the main anti-ischemic, pro-
healing and anti-infective effects.
Authors:
Ahmet Burak Simsek, Hazım Alper Gursu, Emine Azak,
Yasemin Ozdemir Sahan, Ayse Esin Kibar Gul, Funda Kurt,
Ibrahim Ilker Cetin
The authors aimed to determine whether systolic and
diastolic functions of patients who presented to the
pediatric emergency clinic because of carbon monoxide
poisoning and were treated with hyperbaric oxygen
therapy. These patients were examined with tissue
doppler imaging method before and after the treatment.
Authors:
Gonzalo Monge-Martínez, Matías Otto-Yáñez, Nicole
Norambuena, Verónica Martínez, Daniela Retamales,
Rodrigo Torres-Castro
This study aims to analyze the safety of the hyperbaric
oxygen treatment at 1.45 atmosphere absolute (ATA) and
compare it with reports at the same and higher pressures
of treatment.
Authors:
Katarzyna Latusek, Adrianna Słotwinska-Pawlaczyk,
Aleksandra Warakomska, Magdalena Kubicka-Musiał, Rafał
Wiench, and Bogusława Orzechowska-Wylegała
Periodontitis is a chronic inflammatory disease with
multifactorial aetiology. The relationship between
periodontal disease and systemic diseases such as
diabetes, obesity, metabolic syndrome, atherosclerotic,
cardiovascular disease, and cognitive disorders has been
the subject of many studies. The purpose of this study was
to evaluate the effectiveness of hyperbaric oxygen therapy
on periodontal health in patients suffering from
periodontitis and type 2 diabetes.
Authors:
Connor T. A. Brenna, Shawn Khan, Rita Katznelson,
Katherine Marseu
Neurologic injury is relatively common in the context of
spinal surgery, and is often treated with physiotherapy,
pharmacotherapy, or surgical intervention. Emerging
evidence supports a possible role
for hyperbaric oxygen therapy (HBOT) in the treatment of
peripheral and spinal nerve injuries. The authors describe
the successful use of HBOT in improving neurologic
recovery after complex spine surgery with new-onset
postoperative unilateral foot drop.
Authors:
Alain Boussuges, Guillaume Chaumet, Martin Boussuges,
Amelie Menard, Stephane Delliaux, and Fabienne
Brégeon
Although previous studies have determined limit values of
normality for diaphragm excursion and thickening, it
would be beneficial to determine the normal diaphragm
motion-to-inspired volume ratio that integrates the activity
of the diaphragm and the quality of the respiratory system.
Authors:
Clément Leveque, Simona Mrakic Sposta, Sigrid
Theunissen, Peter Germonpré, Kate Lambrechts,
Alessandra Vezzoli, Maristella Gussoni, Morgan Levenez,
Pierre Lafère, François Guerrero, Costantino Balestra
This study investigated the metabolic responses of hypoxic
breathing for one hour to inspired fractions of 10% and
15% oxygen. To this end blood samples of 14 nonsmoking
volunteers were taken before and at 30 min, 2 h, 8 h, 24
h, and 48 h after exposure. The level of oxidative stress
was evaluated while antioxidant systems were observed in
terms of the total antioxidant capacity (TAC) and urates.
Authors: Kent J. MacLaughlin, gregory P. Barton,
udolf K. Braun, Julia E. MacLaughlin, Jacob J. Lamers,
Mathew D. Marcou, and Marlowe W. Eldridge
Hyperbaric air (HBA) was first used pharmaceutically in
1662 to treat lung disease. Extensive use in Europe and
North America followed throughout the 19th century to
treat pulmonary and neurological disorders.
Since that time the 78% Nitrogen fraction in HBA has
been completely displaced by 100% oxygen to create the
modern pharmaceutical hyperbaric oxygen therapy
(HBOT), a powerful treatment that is approved for multiple
indications.
Authors:
Olivier Castagna, Arnaud Druelle, Guillaume Michoud,
Thibaut Prevautel, and Jean René Lacour
Immersion pulmonary edema (IPE) is a frequent diving
accident, and it is the primary cause of hospitalization for
young military divers during training. The objective of this
study was to identify immersion-induced parameters
predicting individual susceptibility to IPE.
Authors:
Feiko J. M. de Jong, Thijs T. Wingelaar, Rob A. van Hulst
This paper is a summary of the various methods
implemented to control the adverse effects of oxygen.
Authors:
Jan-Peter Schaap, Margy E Zuluaga Fernandez, Antoinette
Houtkooper , Edwin L Endert, Pieter-Jan AM van Ooij
In the diving community there is a special need to know if
asymptomatic or mild COVID-19 disease impacts the
cardiopulmonary functioning of individuals with
occupational exposure to extreme environments. To date,
no controlled studies have been conducted comparing
COVID-19-infected hyperbaric employees and non-
COVID-19-infected peers in a military setting.
Authors: Betul Onal Gunay
Paracentral acute middle maculopathy (PAMM) is a
structural optical coherence tomography (OCT) sign
secondary to ischemia in the intermediate and deep
retinal vascular network, characterized by hyper-reflectivity
in the inner nuclear layer (INL).
The aim of the authors is to demonstrate PAMM
development following uncomplicated cataract surgery,
possibly triggered by fasting and dehydration. They also
aim to emphasize the potential role of hyperbaric oxygen
therapy in treating PAMM.
Authors:
Ran Arieli
Pulmonary oxygen toxicity (POT) is a major risk in diving
while breathing hyperoxic gas and is also considered in
clinical hyperbaric oxygen treatment. The author shows
that the pulmonary oxygen toxicity index calculated by the
power equation
offers a better prediction
than other suggested approaches.
Authors:
Piotr H. Skarzynski, Aleksandra Kolodziejak, Elzbieta Gos,
Magdalena B. Skarzynska, Natalia Czajka, and
Henryk Skarzynski
This paper describes a retrospective clinical study that was
conducted to test the impact of hyperbaric oxygen
therapy in the treatment of patients with sudden
sensorineural hearing loss.
Authors:
Javed Iqbal, Abdullah Naeem, Kainat Jahangir, Yumna Ali,
Yusra Mashkoor, Ahmer Ashraf, Dalia Mehmood, Maria
Mehmood, and Lucke-Wold Brandon
Hyperbaric oxygen therapy (HBO2) aims to address
ischemia resulting from brain injury by subjecting patients
to an atmosphere that raises the concentration of inspired
oxygen (100% O2 at greater than 1 ATA). This results in
elevated levels of oxygen in the plasma, which in turn
boosts the delivery of oxygen for diffusion to the brain
tissue. This paper study the efficacy of hyperbaric oxygen
(HBO)-based modalities in brain injury
Authors: Arman Vahabi, Merve Mert, Huseyin Aytaç
Erdem, Ilgın Yıldırım Simsir, Meltem Isıkgoz
Tasbakan, and Anıl Murat Ozturk
The purpose of this study is to evaluate the side effects
associated with hyperbaric oxygen therapy and provide
recommendations to prevent them in patients with
diabetic foot ulcers.
Authors:
Clément Leveque, Simona Mrakic Sposta, Sigrid
Theunissen, Peter Germonpré, Kate Lambrechts,
Alessandra Vezzoli, Gerardo Bosco, Morgan Lévénez,
Pierre Lafère, François Guerrero, and Costantino Balestra
Hyperbaric oxygen therapy (HBOT) is a therapeutical
approach based on exposure to pure oxygen in an
augmented atmospheric pressure. Although it has been
used for years, the exact kinetics of the reactive oxygen
species (ROS) between different pressures of hyperbaric
oxygen exposure are still not clearly evidenced. In this
study, the metabolic responses of hyperbaric hyperoxia
exposures for 1 h at 1.4 and 2.5 ATA were investigated.
Authors:
Eva Maria Martin, Sven Rupprecht, Simon Schrenk, Fabian
Kattlun, Isabelle Utech, Monique Radscheidt, Stefan
Brodoehl, Matthias Schwab, Philipp A. Reuken, Andreas
Stallmach, Thomas Habekost, Kathrin Finke
The authors assumed that cognitive dysfunction and
fatigue in post-COVID syndrome are critically linked via
hypoarousal of the brain. Thus, we assessed whether tonic
alertness as a neurocognitive index of arousal is reduced in
these patients and how this relates to the level of central
nervous activation and subjective mental fatigue as further
indices of arousal.
Authors:
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto
F. Barak, Ivan Drvis, Benjamin S. Stacey, Angelo Iannetelli,
Gareth W. Davison, Rasmus H. Dahl, Ronan M.G. Berg,
David B. MacLeod, Zeljko Dujic, & Philip N. Ainslie
Voluntary asphyxia induced by apnea in competitive
breath hold (BH) divers affords a unique opportunity to
examine integrated mechanisms underlying the
preservation of cerebral bioenergetic function.
This study examined to what extent physiological extremes
of oxygen (O2) demand and carbon dioxide (CO2 )
production impact redox homeostasis and corresponding
red blood cell (RBC)-mediated cerebral vasodilation.
Authors:
Matteo Paganini, Giuseppe Cantarella, Danilo Cialoni, Ezio
Giuffrè, & Gerardo Bosco
As a diagnostic tool, ultrasound was first developed to
explore anatomic areas in which standard radiography
had limited applications and accuracy, such as the
abdomen, the heart, arteries, and veins. Surprisingly,
ultrasound has become a fundamental tool for clinicians.
After creating portable apparatuses, point-of-care
ultrasound (POCUS) has implemented the traditional
physical exam so that real-time insonation and
interpretation allow the clinician to confirm or reject
diagnostic hypotheses at the bedside.
Authors:
Nicolas Vallée, Emmanuel Dugrenot, Anne-Virginie
Desruelle, Simone Richard, Stéphane Coupé, Céline
Ramdani, Régis Guieu, Jean-Jacques Risso, Sandrine
Gaillard, & François Guerrero
Decompression sickness (DCS) with neurological disorders
includes an inflammatory response which degenerates
slowly, even after the disappearance of the bubbles. There
is high inter-individual variability in terms of the
occurrence of DCS that could have been mastered by the
selection and then the breeding of DCS-resistant rats. The
authors hypothesized the selection of single-nucleotide
polymorphisms (SNPs) linked to autoimmunity operated
upon a generation of a DCS-resistant strain of rats.
Authors:
Costantino Balestra, Simona Mrakic-Sposta, and Fabio
Virgili
Nowadays, the therapeutic use of oxygen is not only
limited to restoring hypoxia, but several newly developed
approaches use oxygen not only as a “restoring agent”
but also as a potent stimulus. Salvagno et al. based their
review on the paradoxical response of the intermittent
shift between hyperoxic–normoxic exposure, which was
shown to enhance erythropoietin production and raise
hemoglobin levels with numerous different potential
applications in many fields of therapy as a new strategy for
surgical preconditioning aimed at frail patients and
prevention of postoperative anemia.
Authors:
Eyal Bar-Kochba, Alexander S. Iwaskiw, Jenna M. Dunn,
Jenna M. Dunn, Timothy P. Harrigan, and Constantine K.
Demetropoulos
This study presents an experimental characterization of
isolated human lung dynamics during simulated
exposureto underwater shock waves.
The authors found that the large acoustic impedance at
the surface of the lung severely attenuated transmission of
the shock wave into the lungs.
Authors:
Benjamin Simonnet, Romain Roffi, Henri Lehot, Jean
Morin, Arnaud Druelle, Lucille Daubresse, Pierre Louge,
Sébastien de Maistre, Emmanuel Gempp, Nicolas Vallee,
and Jean-Eric Blatteau
Spinal cord decompression sickness (scDCS) unfortunately
has a high rate of long-term sequelae. The purpose of this
study was to determine the best therapeutic management
in a hyperbaric center and, in particular, the influence of
hyperbaric treatment performed according to tables at 4
atm (Comex 30) or 2.8 atm abs (USNT5 or T6 equivalent).
Authors:
Owen J. ONeill, Anthony Haftel, Heather M. Murphy-
Lavoie
Despite all attempts to mitigate risk, tunnel compressed air
workers may still suffer the signs and symptoms of DCS
and a variety of other typical construction work-related
hazards.
This paper discusses discuss compressed air workers
performance in dry hyperbaric environments, particularly
those pertaining to tunnel and caisson work, as well as the
different methods of compression used to keep them safe
and the job productive and cost-effective.
